I have a love/hate relationship with Wacom tablets. They’re awesome when they work, but that’s rare, because the drivers are crap. And that’s on a Mac, where a lot of people actually use them.
I installed one on my Linux machine, and from that day forward, the mouse just lived a life of its own — jumping around and generally acting stupid.
So today, on a hunch, I decided to uninstall the Wacom drivers. It seems to have calmed the mouse down a little, but it still randomly jumps a couple of hundred pixels away from where it ought to be.